AI-assisted organoid engineering

Organoids, three-dimensional miniature organ-like structures cultivated from stem cells, offer an unparalleled opportunity to simulate complex human organ systems in vitro. The convergence of organoid technology and AI enables comprehensive analysis of intricate organoid behaviors, intricate cellular interactions, and dynamic responses to stimuli. This synergy empowers the development of predictive models, precise disease simulations, and personalized medicine approaches, revolutionizing our understanding of human development, disease mechanisms, and therapeutic interventions. Our long-term goal is to integrate organoid technology with machine learning, AI, and systems biology to advance organoid-based drug screening and disease modeling.

Scalable stem cell extracellular vesicle therapeutics

Stem cell extracellular vesicles (EVs) with therapeutic potential via several simultaneous actions: inhibit inflammation, modulate immune responses, reduce cell apoptosis, and enhance tissue repair and regeneration. Challenges in EV translation are low production and insufficient quality control. Development of advanced biomanufacturing processes is needed to generate both clinically relevant quantity and GMP-grade quality as trials of EVs progress towards large patient numbers. Our long-term goal is to gain fundamental understanding of biogenesis process, physiochemical properties, and biological functions of EVs to further advance scalable and standardized biomanufacturing of high-quality stem cell EVs.